Antidepressants: Safe during pregnancy? Taking medications during pregnancy can have risks and benefits. Get the facts about antidepressant use during pregnancy. Antidepressants are a primary treatment option for most types of depression. But there are benefits and risks to consider when taking antidepressants during pregnancy. Here's what you need to know. Why is treatment for depression during pregnancy important? If you have untreated depression, you might not seek optimal prenatal care or eat the healthy foods you and your baby need. Experiencing major depression during pregnancy is associated with an increased risk of premature birth, low birth weight, decreased fetal growth or other problems for the baby. Unstable depression during pregnancy also increases the risk of postpartum depression and difficulty bonding with your baby. Are antidepressants an option during pregnancy? Yes. A decision to use antidepressants during pregnancy, in addition to counseli...